{"id":4827,"date":"2020-10-23T02:54:59","date_gmt":"2020-10-22T23:54:59","guid":{"rendered":"https:\/\/groupflorence.com\/en\/?page_id=4827"},"modified":"2023-12-05T15:43:18","modified_gmt":"2023-12-05T12:43:18","slug":"molecular-oncology-and-genetics","status":"publish","type":"page","link":"https:\/\/groupflorence.com\/en\/centers-treatments\/oncology-center\/molecular-oncology-and-genetics\/","title":{"rendered":"Molecular Oncology and Genetics"},"content":{"rendered":"<section id=\"bt_section69ec13aedd7a9\"  class=\"boldSection gutter\" ><div class=\"port\"><div class=\"boldCell\"><div class=\"boldCellInner\"><div class=\"boldRow  \" ><div class=\"boldRowInner\"><div class=\"rowItem col-md-4 col-ms-12 btTextLeft\"  ><div class=\"rowItemContent\" ><div class=\"btClear btSeparator topSpaced noBorder\" ><hr><\/div><div class=\"btCustomMenu treatment-sidebar\" ><div class=\"menu-oncology-center-container\"><ul id=\"menu-oncology-center\" class=\"menu\"><li id=\"menu-item-3501\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-3501\"><a href=\"https:\/\/groupflorence.com\/en\/centers-treatments\/\">Centers &#038; Departments<\/a><ul class=\"sub-menu\"><li id=\"menu-item-3497\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-3497\"><a href=\"https:\/\/groupflorence.com\/en\/centers-treatments\/oncology-center\/\">Comprehensive Oncology Center<\/a><ul class=\"sub-menu\"><li id=\"menu-item-4380\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-4380\"><a href=\"https:\/\/groupflorence.com\/en\/centers-treatments\/oncology-center\/nuclear-oncology-nuclear-medicine\/\">Nuclear Oncology (Nuclear Medicine)<\/a><\/li><li id=\"menu-item-4832\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-4832\"><a href=\"https:\/\/groupflorence.com\/en\/centers-treatments\/oncology-center\/molecular-oncology-and-genetics\/\">Molecular Oncology and Genetics<\/a><\/li><li id=\"menu-item-4376\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-4376\"><a href=\"https:\/\/groupflorence.com\/en\/centers-treatments\/oncology-center\/medical-oncology-and-immunotherapy\/\">Medical Oncology and Immunotherapy<\/a><\/li><li id=\"menu-item-4952\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-4952\"><a href=\"https:\/\/groupflorence.com\/en\/centers-treatments\/oncology-center\/radiation-oncology\/\">Radiation Oncology<\/a><\/li><li id=\"menu-item-4373\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-4373\"><a href=\"https:\/\/groupflorence.com\/en\/centers-treatments\/oncology-center\/interventional-radiology-in-oncology\/\">Interventional Radiology in Oncology<\/a><\/li><li id=\"menu-item-3513\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-3513\"><a href=\"https:\/\/groupflorence.com\/en\/centers-treatments\/oncology-center\/why-florence-nightingale-oncology-center\/\">Why Florence Nightingale Oncology Center?<\/a><\/li><li id=\"menu-item-3506\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-3506\"><a href=\"https:\/\/groupflorence.com\/en\/centers-treatments\/oncology-center\/multidisciplinary-tumor-board\/\">Multidisciplinary Tumor Board<\/a><\/li><\/ul><\/li><\/ul><\/li>\n<\/ul><\/div><\/div><div class=\"btClear btSeparator topSemiSpaced noBorder\" ><hr><\/div><div class=\"boldRow boldInnerRow  bt_bb_hidden_xs bt_bb_hidden_ms bt_bb_hidden_sm\" ><div class=\"rowItem rowInnerItem col-md-12  btTextCenter btMiddleVertical\"  ><div class=\"rowItemContent\"><div class=\"bpgPhoto btTextCenter\" > \r\n\t\t\t\t\t<a href=\"https:\/\/groupflorence.com\/en\/patient-guide\/covid-19-precautions\/\" target=\"_blank\" title=\"\"><\/a>\r\n\t\t\t\t\t<div class=\"boldPhotoBox\"><div class=\"bpbItem\"><div class = \"btImage\"><img decoding=\"async\" src=\"https:\/\/groupflorence.com\/en\/wp-content\/uploads\/2020\/12\/covid-safe-sidebar-320x186.jpg\" alt=\"\" title=\"\" ><\/div><\/div><\/div>\r\n\t\t\t\t\t<div class=\"captionPane\">\r\n\t\t\t\t\t\t<div class=\"captionTable\">\r\n\t\t\t\t\t\t\t<div class=\"captionCell\">\r\n\t\t\t\t\t\t\t\t<div class=\"captionTxt\"><\/div>\r\n\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div><\/div><div class=\"btClear btSeparator topSmallSpaced bottomSmallSpaced border\" ><hr><\/div><a href=\"https:\/\/groupflorence.com\/en\/contact-us\/\" class=\"btBtn btBtn btnFilledStyle btnAccentColor btnBig btnNormalWidth btnLeftPosition btnNoIcon\" ><span class=\"btnInnerText\">Ask A Question<\/span><\/a><\/div><\/div><\/div><\/div><\/div><div class=\"rowItem col-md-8 col-ms-12 btTextLeft\"  ><div class=\"rowItemContent\" ><div class=\"btClear btSeparator topSemiSpaced noBorder\" ><hr><\/div><header class=\"header btClear medium btDash bottomDash  btNormalDash\" ><div class=\"dash\"><h3><span class=\"headline\"><b class=\"animate\">Molecular Oncology and Genetics<\/b><\/span><\/h3><\/div><\/header><div class=\"btClear btSeparator topSemiSpaced noBorder\" ><hr><\/div><div class=\"btText\" ><\/p>\n<p>Genetic tests in cancers have become specified to person (tailor-made). The genetic tests can be used for helping diagnosis, modifying follow-up procedure, predicting prognosis and the selection of the right medicine for the oncological patients. Disorders causing cancer, genetic mutations, gene increase, deletion, translocation and other abnormalities are detected with genetic tests.<\/p>\n<p>In our Genetic Diagnosis Center which is licenced by the Ministry of Health and having the certificates of United Kingdom National External Quality Assessment Service (UKNEQAS), Munich Ludwig Maximilian University (LMU) all cytogenetic, moleculocytogenetics and molecular genetics tests for cancer diagnosis, treatment and prognosis, which are regulated by National Compherensive Cancer Network (NCCN), are run from blood, bone marrow, cell culture, fresh tumor tissue and paraffin blocks.<\/p>\n<h3>Personalised \/ Tailor-made Genetic Tests<\/h3>\n<p>All chromosomal abnormalities, translocations, deletions causing hematological cancer are detected with conventional cytogenetic and cytomolecular methods at the Genetic Diseases and Diagnostic Center. Morever, we perform \u00a0\u201cdirect DNA sequencing\u201d to define any distinct or indistinct mutations for oncologic and genetic diseases.<\/p>\n<p>Along with hematologic cancer, we perform genetic analysis for breast, colorectal, lung, and prostate cancers. We try to define not only diagnostic, but also prognostic genetic factors (factors that will affect treatment success, and patient outcome) before planning treatment.<\/p>\n<h3>Breast Cancer<\/h3>\n<p>BRCA1 and BRCA2 are the genes relevant to the risk of breast and ovary cancer. It is known that the existence of a mutation on these genes increases the risks of breast and overy cancer and with a lower portion, colon and pancreatic cancer among the women and risks of breast and prostate cancer among the men. Lifelong breast cancer risk among all the women in the society is calculated as %13.2, on the other hand, the same risk is calculated as %36-85 among the women who carry the mutated forms of BRCA1 or BRCA2 genes. In our center, known or unknown mutation existence is analyzed by scanning the axon belonging to genes with \u201cdirect DNA sequencing\u201d method. Fish and Her2 Neu Gen amplification are operated from breast tissue paraffin block.<\/p>\n<h3>Colorectal Cancer<\/h3>\n<p>K-ras is a proto-oncogenic. K-ras gene connects to the GTP with an external stimulus stimulating the cell growth and division and plays a physiological role in cell growth and division by becoming active and transferring the stimulus to the intracellular message line. It has gained importance to determine the treatment method according to examination of the Kras genetic area consisting of 7 parts and after the examination whether genetic changes are found or not in patients with large intestine cancer. It is determined that Mutation of the part named as kodon 12 and 13 and located in 1st exo of the Kras gene leads the resistance to medicine in patients. For this reason, the examination of this area before the treatment determines the treatment approach. Accordingly, it is emphasized that the similar approach is important for the patients in head and neck region cancers.<\/p>\n<h3>Lung Cancer<\/h3>\n<p>Somatic mutations of epidermal growth factor receptors (EGFR) in non- small lung cancers is known as a factor increasing the bioavailability \u201cgefinitib\u201d treatment used as EGFR inhibitor. According to the fact that the EGFR DNA analysis is able to lead the treatment protocol in patients with lung and pancreatic cancer and according to the scientific date obtained from the studies mutations frequently exist on 18, 19, 20 and 21st exon. Primers have been designed and optimization has been realized in order to be able to make the sequence analysis of these four important exons. In our center, mutations can be detected by investigating sequence analysis of these four important exons. EGFR, ROS1 amplification and ALK EML\/ALK t(2;5) translocation\/ fusion are looked with fish.<\/p>\n<p>MDR1,MDR2, MRP1, MRP2, cytidine deaminase, timidilate synthase Gene Expression Analysis: Tumor cells may develop resistance to one or more cytostatics with various mechanisms. The resistance generally arises from the spontaneous mutations in cancer cells. Resistant phenotype comes out early period when it cannot be determined in clinic. Treatments in which the medicines having different affect mechanism are used in a combination and made in an early period before resistant cell populations come out increase the success of the cancer treatment. Medicine resistance is the most important handicap for the success of the treatment of both small cell and non-small cell lung cancer. MDR1,MDR2, MRP1, MRP2, cytidine deaminase, timidilate synthase genes which are responsible for the multiple medicine resistance in lung cancer play an important role in resistance mechanism. In our center gene expression belonging to all these genes can be analyzed quantatively.<\/p>\n<h3>Brain Tumors<\/h3>\n<p>EGFR amplifications in accordance with the cancer type or 1p,19q Co deletions with Fish.<\/p>\n<p>\n<\/div><div class=\"btClear btSeparator topSemiSpaced noBorder\" ><hr><\/div><div class=\"boldRow boldInnerRow  \" ><div class=\"rowItem rowInnerItem col-md-4  btTextCenter inherit btNoPadding\" style=\"border: 1px solid #999;background-color: rgba(241, 241, 241, 1);\" ><div class=\"rowItemContent\"><div class=\"bpgPhoto btTextCenter\" ><div class=\"btImage\"><img decoding=\"async\" src=\"https:\/\/groupflorence.com\/en\/wp-content\/uploads\/2020\/10\/Kanay-Yararbas\u0327.jpg\" alt=\"\" title=\"\"><\/div><\/div><div class=\"btIconImageRow btIconsHalfHoverPosition\" ><\/div><div class=\"btClear btSeparator topSmallSpaced noBorder\" ><hr><\/div><div class=\"btText\" ><\/p>\n<h4><a href=\"https:\/\/groupflorence.com\/en\/doctors\/kanay-yararbas\/\">Assoc. Prof. Kanay Yararba\u015f, MD<\/a><\/h4>\n<p>\n<\/div><div class=\"btClear btSeparator bottomExtraSmallSpaced noBorder\" ><hr><\/div><\/div><\/div><div class=\"rowItem rowInnerItem col-md-4  btTextCenter inherit btNoPadding\" style=\"background-color: rgba(241, 241, 241, 1);\" ><div class=\"rowItemContent\"><\/div><\/div><div class=\"rowItem rowInnerItem col-md-4  btTextCenter inherit btNoPadding\" style=\"background-color: rgba(241, 241, 241, 1);\" ><div class=\"rowItemContent\"><\/div><\/div><\/div><div class=\"btClear btSeparator topSemiSpaced noBorder\" ><hr><\/div><header class=\"header btClear medium btDash bottomDash  btAccentDash\" ><div class=\"dash\"><h3><span class=\"headline\"><em>Contact Us Now<\/em><\/span><\/h3><\/div><\/header><div class=\"btClear btSeparator bottomSmallSpaced noBorder\" ><hr><\/div><div class=\"btText\" >\n<div class=\"wpcf7 no-js\" id=\"wpcf7-f2891-o1\" lang=\"tr-TR\" dir=\"ltr\" data-wpcf7-id=\"2891\">\n<div class=\"screen-reader-response\"><p role=\"status\" aria-live=\"polite\" aria-atomic=\"true\"><\/p> <ul><\/ul><\/div>\n<form action=\"\/en\/wp-json\/wp\/v2\/pages\/4827#wpcf7-f2891-o1\" method=\"post\" class=\"wpcf7-form init wpcf7-acceptance-as-validation\" aria-label=\"\u0130leti\u015fim Formu\" novalidate=\"novalidate\" data-status=\"init\">\n<div style=\"display: none;\">\n<input type=\"hidden\" name=\"_wpcf7\" value=\"2891\" \/>\n<input type=\"hidden\" name=\"_wpcf7_version\" value=\"6.0.6\" \/>\n<input type=\"hidden\" name=\"_wpcf7_locale\" value=\"tr_TR\" \/>\n<input type=\"hidden\" name=\"_wpcf7_unit_tag\" value=\"wpcf7-f2891-o1\" \/>\n<input type=\"hidden\" name=\"_wpcf7_container_post\" value=\"0\" \/>\n<input type=\"hidden\" name=\"_wpcf7_posted_data_hash\" value=\"\" \/>\n<\/div>\n<p style=\"margin-bottom:30px !important;\">While filling up the contact form below, you can alsosend us your\/patient\u2019s medical files by <strong>wetransfer<\/strong>. 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